Preoperative Molecular Markers in Thyroid Nodules
نویسندگان
چکیده
منابع مشابه
Molecular markers in the diagnosis of thyroid nodules.
An indeterminate thyroid nodule cytology result occurs about every sixth fine-needle aspiration. These indeterminate nodules harbor a 24% risk of malignancy (ROM); too high to ignore, but driving surgery where most nodules are benign. Molecular diagnostics have emerged to ideally avoid surgery when appropriate, and to trigger the correct therapeutic surgery when indicated, as opposed to an inco...
متن کاملPreoperative Prediction of the Risk of Malignancy in Thyroid Nodules
Objective: This study aimed to propose a formula for predicting the biological nature of thyroid nodules, thus helping in clinical decision making and avoiding unnecessary surgery. Patients and methods: Prospective, longitudinal and observational study was conducted on 400 patients submitted to primary thyroid surgery at the Department of Surgery, University of Pisa, Italy, between April 1st an...
متن کاملPredicting malignancy in thyroid nodules: molecular advances.
Over the last several years, a clearer understanding has developed of the genetic alterations underlying thyroid carcinogenesis. This knowledge can be used to tackle 1 of the challenges facing thyroidologists: management of the indeterminate thyroid nodule. Despite the accuracy of fine-needle aspiration cytology, many patients undergo surgery to diagnose malignancy and better diagnostic tools a...
متن کاملNew strategies in diagnosing cancer in thyroid nodules: impact of molecular markers.
Thyroid cancer is the most common type of endocrine malignancy, with approximately 55,000 new cases diagnosed in the United States in 2012. However, thyroid nodules are much more prevalent, particularly with increased age, and only a small fraction of those are malignant. Therefore, the major clinical challenge is to reliably differentiate those nodules that are malignant and need to be treated...
متن کاملDiagnostic use of molecular markers in the evaluation of thyroid nodules.
OBJECTIVE To describe the molecular markers thus far evaluated for use in the care of patients with clinically relevant thyroid nodules. METHODS We review the currently available molecular tests that have been applied to patients with thyroid nodules. RESULTS In the United States, approximately 450 000 diagnostic fine-needle aspirates will be performed on patients with thyroid nodules this ...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2018
ISSN: 1664-2392
DOI: 10.3389/fendo.2018.00179